N-phenylalkyl substituted .alpha.-amino carboxamide derivatives and process for their preparation
US5502079A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 17, 1994 |
| Grant date | Mar 26, 1996 |
| Priority date | — |
| Expiry date | Nov 17, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/32
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
N-phenylalkyl substituted .alpha.-amino carboxamide derivatives of formula (I) ##STR1## wherein R is C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, furyl, thienyl, pyridyl or unsubstituted or substituted phenyl; A is a --(CH.sub.2).sub.m -- or --(CH.sub.2).sub.p --X--(CH.sub.2).sub.q -- group wherein X is --O--, --S-- or --NR.sub.4 --; R.sub.1, R.sub.2, R.sub.3, R'.sub.3, R.sub.4, n, m, p and q are as herein defined; and each of R.sub.5 and R.sub.6 is independently hydrogen or C.sub.1 -C.sub.6 alkyl, and the pharmaceutically acceptable salts thereof, are active on the central nervous system and can be used as anti-epileptic, anti-Parkinson, neuroprotective, antidepressant, antispastic and/or hypnotic agents in mammals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.