Patent · US Expired

Process for preparing sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxymet hyl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate

US5502199A · kind A · utility

6Cited by

4References

8Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Rolf Angerbauer · Wuppertal, DE
Rolf Grosser · Schwandorf, DE
Werner Hinsken · Essen, DE
Joachim Rehse · Leichlingen, DE

Key dates

Filing date	Mar 17, 1994
Grant date	Mar 26, 1996
Priority date	—
Expiry date	Mar 17, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Enantiomerically pure sodium 3R,5S-(+)-erythro-(E)-7- 4-(4-fluorophenyl)-2,6-diisopropyl-5-methoxy-meth yl-pyrid-3-yl!-3,5-dihydroxy-hept-6-enoate is prepared by initially cyclizing a corresponding racemic ester to give the racemic lactones and then separating the latter by chromatography on a chiral stationary phase. Cleavage of the enantiomerically pure lactones with the aid of a base yields the enantiomerically pure end products.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.