Process for preparing delta 9,11 and 21-chloro corticosteroids
US5502222A · kind A · utility
16Cited by
5References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 1994 |
| Grant date | Mar 26, 1996 |
| Priority date | — |
| Expiry date | Jun 1, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Described is a process for the regioselective dehydration of 11-hydroxy steroids using PCl.sub.5, PCl.sub.3, POCl.sub.3 or either SO.sub. Cl.sub.2 and imidazole, or PPh.sub.3 and CCl.sub.4. The disclosed process selectively forms .increment..sup.9,11 steroids from either 11-.alpha.- or 11-.beta.-hydroxy steroids, and can also be used for the one-step conversion of 11,21-dihydroxy steroids to 21-chloro-.increment..sup.9,11 steroids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.