DNA encoding the 15kD outer membrane protein of Haemophilus influenzae
US5503992A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 7, 1993 |
| Grant date | Apr 2, 1996 |
| Priority date | — |
| Expiry date | Sep 7, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Murine monoclonal antibodies directed against a novel outer membrane protein (OMP) of Haemophilus influenzae have been isolated and characterized. The gene encoding of the outer membrane protein has also been isolated and characterized. Portions of the DNA sequence of the 15 kD OMP gene are useful as probes to diagnose the presence of Haemophilus influenzae in samples. These DNA's also make available polypeptide sequences of immunoreactive epitopes encoded within the gene, thus permitting the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. Monoclonal antibodies directed against epitopes of the 15 kD OMP are also useful for diagnostic tests and as therapeutic agents for passive immunization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.