Modification of DNA and oligonucleotides using metal complexes of polyaza ligands

US5504075A · kind A · utility

Assignee

• The Research Foundation of the State University of New York · US

Inventors

• Cynthia J. Burrows · Stony Brook, US
• Steven E. Rokita · Port Jefferson, US
• Xiaoying Chen · Nanhu, CN

Key dates

• Filing date: Sep 28, 1993
• Grant date: Apr 2, 1996
• Expiry date: Sep 28, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/68
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.