Method for resolving racemic compounds
US5504221A · kind A · utility
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23Claims
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Key dates
| Filing date | Mar 2, 1995 |
| Grant date | Apr 2, 1996 |
| Priority date | — |
| Expiry date | Mar 2, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/68
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for resolving racemic dimethyl-4,4'-dimethoxy-5,6,5',6'-di(methylenedioxy)biphenyl-2,2'-dicarbox ylate ("DDB"), in which a chiral .alpha.-alkyl benzyl alcohol is used as the resolving agent. More specifically, racemic DDB is first hydrolyzed to form dicarboxylic acid, which is then reacted with chiral .alpha.-alkyl benzyl alcohol to form two chiral isomers. The chiral isomers, after separation either by chromatography or by recrystalli-zation, are respectively hydrogenated and esterified to form chiral DDB isomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.