Insulin derivatives, a process for the preparation thereof, the use thereof, and a pharmaceutical formulation containing them

US5506202A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Laszlo Vertesy · Eppstein, DE
• Karl Geisen · Frankfurt, DE
• Gunther Riess · Frankfurt am Main, DE
• Klaus Sauber · Schwalbach, DE

Key dates

• Filing date: May 16, 1995
• Grant date: Apr 9, 1996
• Expiry date: May 16, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

New insulin derivatives, a process for their preparation and use, and a pharmaceutical formulation containing them are disclosed. The derivatives contain the basic amino acid arginine at the amino-terminal position of the insulin A-chain, and various amino acid substitutions at the carboxyl terminus of the insulin B-chain. The compounds are suitable for the treatment of diabetes mellitus, have a delayed profile of action and are very well tolerated.