Phosphonates as anti-cancer agents
US5506217A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 1994 |
| Grant date | Apr 9, 1996 |
| Priority date | — |
| Expiry date | Nov 10, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4081
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention pertains to the synthesis and usc as anti-cancer therapeutic agents of a group of substances with a glycerol backbone linked to phosphonocholinc, or other phosphorus-containing head groups, of the following formula: ##STR1## wherein n is 0 to 14 and R.sub.1 is an alkyl group containing 12 to 20 carbon atoms, R.sub.2 is a methyl group, n=0 to 14 and m=2 to 10, or enantiomer thereof, or mixture of stereoisomers. This invention also pertains to the following formula: ##STR2## wherein n is 15 to 17; R1 is an alkyl group: m is 0 to 2; T is an oxygen atom or a methylene; and R.sub.2 is a choline group and therapeutically effective pharmaceutically acceptable salts thereof. These thiophosphonolipids are useful for treating cancer in a mammal in need of cancer treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.