Compounds bearing sulphamoyl and amidino radicals, their preparation process and pharmaceutical compositions containing them

US5506258A · kind A · utility

Assignee

• Societe Anonyme: Elf Sanofi · FR

Inventors

• Bernard Christophe · Brussels, BE
• Loic Foulon · Cugnaux, FR
• Alain Pellet · Tassin-la-Demi-Lune, FR
• Claudine Serradeil-Le Gal · Paris, FR
• Gerard Valette · Ramonville-Saint-Agne, FR

Key dates

• Filing date: Feb 14, 1994
• Grant date: Apr 9, 1996
• Expiry date: Feb 14, 2014

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The subject of the invention is the compounds of formula I ##STR1## in which Ar.sub.1 represents naphtyl, phenyl, quinolyl or isoquinolyl optionally substituted; PA1 Ar.sub.2 represents a phenyl or thienyl optionally substituted; PA1 R.sub.1, R.sub.2 and R'.sub.2 are independently of each other, H or (C.sub.1 -C.sub.4)alkyl; PA1 R.sub.1 represents nothing and N is attached to Ar.sub.2, and optionally R.sub.2 and R'.sub.2 form a double bond; or R.sub.1 or R.sub.2 is attached to Ar.sub.2 and represents a (C.sub.1 -C.sub.3)alkylene; PA1 R.sub.3 and R.sub.4, which are identical or different, represent H, (C.sub.1 -C.sub.4)alkyl or form, with the nitrogen atom to which they are attached, a (C.sub.5 -C.sub.7) saturated heterocycle selected from pyrrolidine, piperidine and hexahydroazepine; PA1 Z.sub.1 represents a (C.sub.1 -C.sub.12)alkylene, optionally interrupted or extended by a (C.sub.5 -C.sub.7)cycloalkyl or phenyl; PA1 Q.sub.1 represents methyl, amino, alkoxycarbonylamino, alkylamino, dialkylamino, a (C.sub.5 -C.sub.7) saturated heterocyclic amino group, amidino, alkylamidino, guanidino, alkylguanidino, pyridyl, imidazolyl, pyrimidinyl, indolyl, hydroxy, alkoxy, (C.sub.2 -C.sub.8)a…