Morpholino-subunit combinatorial library and method
US5506337A · kind A · utility
413Cited by
5References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 11, 1994 |
| Grant date | Apr 9, 1996 |
| Priority date | — |
| Expiry date | May 11, 2014 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2219/0072
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of generating a compound capable of interacting specifically with a selected macromolecular ligand is disclosed. The method involves contacting the ligand with a combinatorial library of oligomers composed of morpholino subunits with a variety of nucleobase and non-nucleobase side chains. Oligomer molecules that bind specifically to the receptor are isolated and their sequence of base moieties is determined. Also disclosed is a combinatorial library of oligomers useful in the method and novel morpholino-subunit polymer compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.