2,6-methano-2H-quinolizin derivative as 5-HT.sub.3 -receptor antagonist
US5508287A · kind A · utility
1Cited by
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3Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 16, 1994 |
| Grant date | Apr 16, 1996 |
| Priority date | — |
| Expiry date | Aug 16, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to 5-chloro-2,3-dihydro-2,2-dimethylbenzofuran-7-carboxylic acid-octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester (I), a novel 5-HT.sub.3 -receptor antagonist, its method of preparation, and to its end-use application in the treatment or radio- and chemo-therapeutically-induced nausea and vomiting, in the treatment or pain associated with migraine, in the treatment of cognitive disorders, in treating hallucinatory endogenous psychoses or the type manifested in patients suffering from schizophrenia and mania, for irritable bowel syndrome, and to combat drug abuse.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.