Process for manufacturing DTPA-bis amide magnetic resonance imaging

US5508388A · kind A · utility

Assignee

• MallincKrodt Medical, Inc. · US

Inventors

• Lynn deLearie · University City, US
• Wayne H. T. Lin · Huntleigh, US
• Dennis A. Moore · Chesterfield, US
• David H. White · Ballwin, US

Key dates

• Filing date: May 10, 1995
• Grant date: Apr 16, 1996
• Expiry date: May 10, 2015

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Processes for manufacturing diethylenetriaminepentaacetic acid ("DTPA") bis(amide) magnetic resonance imaging ("MRI") agents are disclosed. Specifically, processes for manufacturing [N,N"-Bis[N-(2-methoxyethyl)carbamoylmethyl]diethylenetriamine-N,N',N"-tri acetato]gadolinium(III) are disclosed.