Patent · US Expired

Asymmetric hydrogenation of beta- or gamma-ketoesters and beta- or gamma-ketoamides

US5508435A · kind A · utility

10Cited by

1References

18Claims

0Family size

Assignee

MERCK & CO., INC. · US

Inventors

Joseph D. Armstrong, III · Westfield, US
Lisa DiMichele · North Plainfield, US
Alan W. Douglas · Monmouth Junction, US
Jennifer L. Keller · Princeton, US
Steven A. King · Gurnee, US
Andrew S. Thompson · Mountainside, US
Thomas R. Verhoeven · Cranford, US

Key dates

Filing date	Jan 5, 1994
Grant date	Apr 16, 1996
Priority date	—
Expiry date	Jan 5, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D207/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

.beta.- or .gamma.-Ketoesters and .beta.- or .gamma.-ketoamides are asymmetrically reduced with a Ru(II)-BINAP derived catalyst at about 40.degree. C. and about 50N/mm.sup.2 of hydrogen in the presence of a strong acid.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.