Production of recombinant human interferon-beta2
US5510472A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 15, 1992 |
| Grant date | Apr 23, 1996 |
| Priority date | — |
| Expiry date | May 15, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/565
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Human interferon-beta.sub.2.sbsb.A and interferon-beta.sub.2.sbsb.B are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B, respectively. The sequence of IFN-.beta..sub.2.sbsb.A cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B. The antiviral activity of such recombinant IFN-.beta..sub.2.sbsb.A and IFN-.beta..sub.2.sbsb.B is demonstrated as well as other biological activity identifying them as human interferons.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.