Selective asymmetric hydrogenation of dehydroamino acid derivatives using rhodium and iridium diphosphinite carbohydrate catalyst compositions
US5510507A · kind A · utility
1Cited by
3References
11Claims
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Key dates
| Filing date | Apr 24, 1995 |
| Grant date | Apr 23, 1996 |
| Priority date | — |
| Expiry date | Apr 24, 2015 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2531/827
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wherein the phosphorous atoms are attached to aromatic groups substituted with electron-donating substituents. Also provided is a means to selectively produce .alpha. amino acids in either the L or the D form, based upon use of a sugar in the ligand with phosphinites attached in an absolute Right-Left or Left-Right configuration, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.