Targeted polymerized liposome contrast agents

US5512294A · kind A · utility

Inventors

• King Chuen Li · Stanford, US
• Mark D. Bednarski · Flint, US
• Richard W. Storrs · San Francisco, US
• Henry Y. Li · Visalia, US
• Francois D. Trooper · Oakland, US
• Curtis Kang Hoon Song · Sunnyvale, US
• Dorothy Sipkins · Evanston, US
• Jeremy Kenji Kuniyoshi · Cupertino, US

Key dates

• Filing date: Aug 5, 1994
• Grant date: Apr 30, 1996
• Expiry date: Aug 5, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/928
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Polymerized liposome particles based upon lipids having a polymerizable functional group and a metal chelator to attach an imaging enhancement agent and lipids having an active targeting group to provide targeted polymerized liposome contrast agents. The polymerized imaging enhancement liposome particles interact with receptor targets holding the image enhancement agent to specific sites providing in vivo study by magnetic resonance, radioactive, x-ray or optical imaging of the expression of molecules in cells and tissues during disease and pathology.