Synthetic liposomes for enhanced uptake and delivery

US5512295A · kind A · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Arthur Kornberg · Portola Valley, US
• Celina Castuma · Olavarría, AR

Key dates

• Filing date: Nov 10, 1994
• Grant date: Apr 30, 1996
• Expiry date: Nov 10, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2984
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Liposomes are prepared comprising a polyhydroxybutyrate calcium polyphosphate complex which provides for uptake of a desired component, particularly nucleotides and nucleic acids. The charged species may be introduced into the lumen of a liposome by incubating liposomes with a solution of the component of interest for sufficient time to provide for introduction of the component into the lumen of the liposome, followed by washing at diminished temperatures. The resulting liposomes may then be used as vehicles for delivery of the lumen component.