Prevention of ibuprofen from forming low melting eutectics with other therapeutic agents in solid dosage forms
US5512300A · kind A · utility
7Cited by
6References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 15, 1992 |
| Grant date | Apr 30, 1996 |
| Priority date | — |
| Expiry date | Sep 15, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/192
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for preparing ibuprofen granulations which exhibit improved stability and resistance to the formation of low melting point eutectics is disclosed. The method includes forging an amalgamation of ibuprofen and an alkali metal in a physical matrix which is suitable for inclusion in a composition without destroying the amalgamation. The stabilized ibuprofen granulation can be combined with other active ingredients and/or excipients to form compositions which have extended shelf life and are resistant to the formation of low melting point eutectics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.