Invitroinhibition of the HIV virus with ionic tungstoniobate compounds

US5512305A · kind A · utility

Inventors

• Michael J. Abrams · Glenmoore, US
• Gerald E. Bossard · King of Prussia, US
• Craig L. Hill · Atlanta, US
• Raymond F. Schinazi · Decatur, US
• Brian Theobald · Beaverton, US

Key dates

• Filing date: Aug 26, 1993
• Grant date: Apr 30, 1996
• Expiry date: Aug 26, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K33/42
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tungstoniobate compounds containing an ion of general formula EQU A.sub.x W.sub.y Nb.sub.a O.sub.b !.sup.p- I where A=P, Si, Ge, x=0 or an integer from 1 to 10, y is an integer from 1 to 10, y is an integer from 1 to 40, a is an integer from 1 to 8, b is an integer from 15 to 150, and p is an integer dependent upon the nature and oxidation state of element A, have been found to be active against viruses including especially HIV and Herpes Simplex. Pharmaceutical compositions and methods of treatment are disclosed.