Enzymatic acylation of 3-hydroxymethyl cephalosporins
US5512454A · kind A · utility
4Cited by
21References
20Claims
0Family size
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Key dates
| Filing date | Feb 3, 1994 |
| Grant date | Apr 30, 1996 |
| Priority date | — |
| Expiry date | Feb 3, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/917
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
O-acylated cephalosporins are produced by reacting 3-hydroxymethylcephalosporins with an acyl donor containing at least three carbon atoms and an enzyme which is a Rodosporidium toruloides esterase, a wheat germ lipase, an Aspergillus niger lipase, an orange peel acetylesterase or a Bacillus subtilis esterase. A preferred enzyme is the esterase from Rodosporidium toruloides ATCC 10657. The enzyme can be used while in whole cells or in soluble or inmobilized form.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.