Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US5512492A · kind A · utility
130Cited by
32References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 18, 1993 |
| Grant date | Apr 30, 1996 |
| Priority date | — |
| Expiry date | May 18, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/805
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity. The preferred biosensor and assay method have the capture molecules immobilized to the waveguide surface by site-specific coupling chemistry. Additionally, the coatings used to immobilize the capture molecules provide reduced non-specific protein adsorption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.