Tricyclic thiazole and oxazole derivatives and pharmaceutical agents containing them

US5512564A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Harald Zilch · Mannheim, DE
• Herbert Leinert · Heppenheim, DE
• Alfred Mertens · Schriesheim, DE

Key dates

• Filing date: Mar 4, 1994
• Grant date: Apr 30, 1996
• Expiry date: Mar 4, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention concerns thiazolo- 2,3-a!pyrrole and oxazolo- 1,2-a!pyrrole derivatives of formula I ##STR1## in which HET represents a heterocyclic ring with 3-7 ring atoms which can be substituted by one, two or three residues R.sup.1 which can be the same or different, PA1 Y represents an oxygen or sulphur atom, or a SO or SO.sub.2 group, PA1 X can be an oxygen or sulphur atom, PA1 R denotes an aliphatic residue with 1-9 C-atoms which can be substituted by phenyl or denotes a phenyl ring or a carbocyclic ring with 7-15 C atoms or a heterocyclic ring system each having 5 or 6 ring atoms, in which the aforementioned phenyl rings, carbocyclic rings or heterocyclic ring system can be substituted once or several times, if desired, and R1-R5 denote hydrogen or an aliphatic residue, as well as their tautomers, enantiomers, diastereomers and physiologically tolerated salts.