Photocleavable derivatives of hydroxyprenesulfonic acids
US5514710A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 11, 1994 |
| Grant date | May 7, 1996 |
| Priority date | — |
| Expiry date | Jan 11, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C309/43
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention describes the synthesis and use of photoactivated (or caged) fluorescent dyes. Upon illumination at less than about 400 nm the caged dyes release highly fluorescent, water soluble hydroxypyrenesulfonic acid dyes according to the following equation: ##STR1## X, Y, and Z are independently sulfonic acid, a sulfonic acid salt, a hydroxyl group, or hydrogen, with at least one of X, Y, and Z being a sulfonic acid or sulfonic acid salt. LINK is either an ether linkage or a carbonate linkage. BLOCK is a caging group whose photolysis results in liberation of a free hydroxypyrenesulfonic acid dye. The caged fluorescent dyes are useful for application in aqueous solutions, including fluids of biological origin. The caged dyes of the present invention are especially useful for flow tagging velocimetry.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.