Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof

US5514716A · kind A · utility

Assignee

• Sterling Winthrop Inc. · US

Inventors

• Madhusudhan Reddy Gowravaram · Waltham, US
• Jeffrey W. Johnson · Rochester Hills, US
• Ewell Cook · Middletown, US
• Robert Wahl · Thousand Oaks, US
• Alan M. Mathiowetz · Waltham, US
• Bruce E. Tomczuk · Richmond, US
• Ashis Saha · Stow, US

Key dates

• Filing date: Feb 25, 1994
• Grant date: May 7, 1996
• Expiry date: Feb 25, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C259/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to a novel class of hydroxamic and carboxylic acid based matrix metalloproteinase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of matrix metalloproteinase induced diseases.