Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
US5516637A · kind A · utility
400Cited by
2References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 10, 1994 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Jun 10, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a fusion protein, comprising a pilin protein or a portion thereof and a heterologous polypeptide (target protein). In a preferred embodiment it relates to a method for displaying the target protein on the outer surface of a bacterial host cell capable of forming pilus. In certain embodiments, it is desirable that the pilus is a receptor for bacteriophage attachment and infection. The F pilus is preferred.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.