Microbiological process for the production of aromatic hydroxy-heterocyclic carboxylic acids
US5516661A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 3, 1995 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Feb 3, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/874
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The microbiological process for the production of hydroxy-heterocyclic carboxylic acid of formula ##STR1## wherein R.sub.1 means a hydrogen or a halogen atom and X means a nitrogen atom or a CR.sub.2 function, wherein R.sub.2 means a hydrogen or halogen atom, starting from the corresponding heterocyclic carboxylic acid. The process is performed so that an aerobic biomass which utilizes nicotinic acid, is cultivated in a molar ratio of nicotinic acid to mineral acid of 1 to 8. The ratio is assured over the entire cultivation phase. The the hydroxylation of the corresponding heterocyclic carboxylic acid of the general formula ##STR2## wherein R.sub.1 and X have the above-mentioned meanings, is performed with the biomass. Under these conditions, strain Pseudomonas acidovorans DSM 7205, strain Pseudomonas acidovorans DSM 7203, strain Alcaligenes faecalis DSM 7204 and strain Arthrobacter crystallopoietes DSM 7202 are concentrated in the cultivation phase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.