Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US5516676A · kind A · utility
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9References
3Claims
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Key dates
| Filing date | Jun 15, 1993 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Jun 15, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/872
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred embodiment the microorganism is Nocardioides albus ATCC55424, Nocardioides albus ATCC55425 or Nocardioides luteus ATCC55426 or the hydrolase enzyme is isolated from the microorganisms.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.