Human D4 dopamine receptor and its uses
US5516683A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 29, 1993 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Apr 29, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variants thereof are provided by the invention. The invention particularly provides recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor at useful levels in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize such useful amounts of human D4 dopamine receptor protein, and methods for characterizing novel psychotropic compounds using such cultures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.