Method of treating endotoxin effects with 2-haloadenosine nucleotide analogs
US5516762A · kind A · utility
5Cited by
5References
3Claims
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Key dates
| Filing date | Oct 15, 1993 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Oct 15, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of treating a mammal exposed to endotoxin in order to reduce the detrimental effects of said endotoxin, comprising administering to said mammal a therapeutically effective amount of a 2-halo-adenosine nucleotide analog. 2-Cloro-ATP is the preferred species of the 2-halo-adenosine nucleotide. The nucleotide used in this treatment inhibits lipo-polysaccharide-induced GTPase activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.