Rapamycin formulation for IV injection
US5516770A · kind A · utility
41Cited by
5References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 22, 1994 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Sep 22, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein is an aqueous, injectable rapamycin solution, obtained by a process consisting of mixing 5 to 30 volume percent of a concentrate solution of rapamycin in propylene glycol, at concentrations of rapamycin ranging from 0.5 mg/ml to 10 mg/ml, with a diluent solution consisting of 0.1 to 10 weight percent of one or more polyoxyethylene sorbitan esters, 10 to 60 weight percent of polyethylene glycol 200, 300 or 400 or a combination thereof and 30 to 89.9 volume percent water, wherein the concentration of rapamycin in the injectable solution ranges from 0.025 mg/ml to 3 mg/ml.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.