Condensed pyrazole derivatives, and androgen inhibitor
US5516777A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 17, 1995 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Jan 17, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P13/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a condensed pyrazole derivative of the Formula (1): ##STR1## (where A denotes CH or N, R.sup.0 and R.sup.3 denote same or different, a hydrogen atom or a lower alkyl group, R.sup.1 and R.sup.2 denote same or different, a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a nitro group or a halogen atom, m denotes 1 or 2, and n denotes 1, 2 or 3, provided that, when n is 2, two R.sup.2 may be connected to each other to form a lower alkylenedioxy group), or its pharmaceutically acceptable salt. This derivative or its salt is excellent in the effect of inhibiting the expression of action of androgen, thereby being excellent in therapeutical effect of benign prostatic hypertrophy, prostatic carcinoma, etc., and has a long lasting of efficacy and high oral absorption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.