Process for preparing cephalosporin compounds
US5516902A · kind A · utility
8Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 14, 1994 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Apr 14, 2014 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chromogenic and fluorogenic substrates for .beta.-lactamase, methods for synthesis thereof and methods for detecting .beta.-lactamase in a sample are provided. The substrates are substantially colorless or substantially nonfluorescent .beta.-lactam compounds which include an electronegative leaving group. The leaving group comprises a carbamate, carbonate, thiocarbamate or thiocarbonate linkage and a fluorescent moiety or a moiety capable of producing a visually detectable colored product. Upon cleavage of the lactam ring by .beta.-lactamase, the leaving group is liberated and fluorescence or a colored product is produced.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.