Process for preparing [IR-(1.alpha.,2.beta.-3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclob utyl]-1,9-dihydro-6H-purin-6-one
US5516903A · kind A · utility
3Cited by
6References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 4, 1994 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Nov 4, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C67/29
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The protected cyclobutanone of the formula ##STR1## is treated with a dialkylaluminum chloride, an alkylaluminum dichloride, a trialkylaluminum compound, hydrogen in the presence of the catalysts ruthenium black or ruthenium on alumina, diphenyl-silane in the presence of tris(triphenylphosphine) rhodium (I) chloride, or iridium tetrachloride to yield the corresponding diprotected cyclobutanol. This compound is useful as an intermediate in the preparation of antiviral agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.