Leukotriene B.sub.4 antagonists
US5516917A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 8, 1994 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Jun 8, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl; PA1 R.sup.1 is alkyl; PA1 R.sup.2 represents alkyl from 1 to 5 carbon atoms, aryl or aryl substituted with halogen or alkyl from 1 to 5 carbon atoms; PA1 R.sup.6 is alkyl; PA1 n is 1 to 5; PA1 p is 0 to 6; PA1 x is 0 or 2; and PA1 R.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine. The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.