Process for preparing cyclic CIS-1-amino-2-alkanols
US5516943A · kind A · utility
11Cited by
1References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 14, 1993 |
| Grant date | May 14, 1996 |
| Priority date | — |
| Expiry date | Sep 14, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A two-step process for the conversion of a trans-1-amino-2-hydroxycycloalkane stereoselectively to a cis-1-amino-2-hydroxycycloalkane is disclosed. The novel step, a one-step hydrolysis with formal inversion, can be used to convert an amide of a trans-1-amino-2-hydroxycycloalkane to a cis-1-amino-2-hydroxycycloalkane. Methods for obtaining the trans-1-amino-2-hydroxycycloalkanes and their amides from alkenes are also disclosed. A preferred process converts indene to cis-1-amino-2-indanol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.