Meta-substituted phenylalanine derivatives

US5518735A · kind A · utility

Assignee

• PENTAPHARM AG · CH

Inventors

• Jörg Stürzebecher · Erfurt, DE
• Helmut Vieweg · Rheinfelden (Baden), DE
• Peter Wikstroem · Oberwil, CH

Key dates

• Filing date: Feb 10, 1993
• Grant date: May 21, 1996
• Expiry date: Feb 10, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

D,L-, L- and D-phenyl alanine derivatives of formula (I) defined in claim 1 in which R.sub.1 is an amidino-, guanidino-, oxamidino-, aminomethyl- or amino group have been discovered which effectively prevent blood coagulation or thrombosis. The antithrombotically active compounds have low toxicity and may be administered by mouth, subcutaneously or intravenously.