Nanoparticulate nsaid compositions
US5518738A · kind A · utility
124Cited by
2References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 9, 1995 |
| Grant date | May 21, 1996 |
| Priority date | — |
| Expiry date | Feb 9, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1676
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition comprising a crystalline NSAID having polyvinylpyrrolidone adsorbed on the surface thereof in an amount sufficient to maintain an effective average particle size of less than about 1000 nm, hygroscopic sugar and sodium lauryl sulfate exhibit greatly reduced gastric irritation following oral administration and/or hastened onset of action due to the substantial redispersion of the solid formulation to nanoparticles in gastric fluid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.