WD-40-derived peptides and uses thereof
US5519003A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 1994 |
| Grant date | May 21, 1996 |
| Priority date | — |
| Expiry date | Feb 1, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/705
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a polypeptide composition effective to alter the activity of a first protein that interacts with a second protein, where the second protein contains at least one WD-40 region. The polypeptides of the present invention typically have between 4 and 50 amino acids whose sequence is the same as a sequence of the same length in the WD-40 region of the second protein. The invention further includes a method of altering the activity of the above described first protein. In one embodiment of the invention the polypeptide composition is effective to alter the activity of a protein kinase C, where the protein kinase C interacts with a second protein, and the second protein contains at least one WD-40 region (e.g., RACK1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.