Phosphonated arylethanolamine compounds with anti-hyperglycemic and/or anti-obesity activity

US5519006A · kind A · utility

Assignee

• SmithKline Beeacham P.L.C. · GB

Inventors

• Lee J. Beeley · Epsom, GB
• John Berge · Kongsberg, NO
• Richard Jarvest · Harlow, GB

Key dates

• Filing date: Mar 30, 1995
• Grant date: May 21, 1996
• Expiry date: Mar 30, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4006
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

##STR1## A compound of formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein R.sup.0 represents a substituted or unsubstituted aryl group; R.sup.1 represents hydrogen or an alkyl group; R.sup.2 represents a moiety of formula (a) wherein R.sup.4 and R.sup.5 each independently represent hydrogen, alkyl, hydroxyalkyl, cycloalkyl or R.sup.4 together with R.sup.5 represents (CH.sub.2).sub.n wherein n is 2, 3 or 4; T represents hydrogen, nitrile or a group --CO.R.sup.s wherein R.sup.s represents hydroxy, alkoxy or a group --NR.sup.t R.sup.u wherein R.sup.t and R.sup.u independently represent hydrogen, alkyl or R.sup.t and R.sup.u together with the nitrogen to which they are attached represent a saturated heterocyclic group; and R.sup.3 represents hydrogen, halogen, alkyl or alkoxy; a process for the preparation of such a compound, a pharmaceutical composition comprising such a compound and the use of such a compound in medicine.