Derivatives of triterpenoid acids as inhibitors of cell-adhesion molecules ELAM-1 (E-selectin) and LECAM-1 (L-selectin)

US5519008A · kind A · utility

Assignee

• Glycomed Incorporated · US

Inventors

• Narasinga Rao · Alameda, US
• Mark B. Anderson · Salt Lake City, US
• John J. Naleway · Eugene, US
• John H. Musser · Alameda, US

Key dates

• Filing date: Sep 10, 1992
• Grant date: May 21, 1996
• Expiry date: Sep 10, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H17/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Triterpenoid acid derivatives have been found to have structures similar to natural ligands to the extent that these derivatives bind to natural selectin receptors including endothelial leukocyte adhesion molecule-1 (ELAM-1) and leukocyte/endothelial cell adhesion molecule-1 (LECAM-1). The molecules can be administered to the patients by themselves or in pharmaceutical formulations; in order to alleviate inflammation and/or treat other abnormalities associated with the excessive binding of leukocytes to endothelial receptors.