Soluble LDL receptor and gene
US5521071A · kind A · utility
8Cited by
1References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 15, 1994 |
| Grant date | May 28, 1996 |
| Priority date | — |
| Expiry date | Apr 15, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A truncation of the human LDL receptor gene has been created which can be expressed in a heterologous host to produce a soluble fragment to the receptor protein. The gene can be expressed in insect cells in culture to produce a protein fragment which is not only water soluble but which also retains affinity for binding to LDL. The truncation is a truncation of the carboxyl terminus of the native LDL receptor gene which results in a 354 amino acid protein fragment designated LDL-R.sup.354.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.