Method for producing oriented connective tissue cells in a ligament configuration
US5521087A · kind A · utility
39Cited by
5References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 9, 1995 |
| Grant date | May 28, 1996 |
| Priority date | — |
| Expiry date | Jan 9, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/54
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention pertains to an oriented tissue-equivalent formed by contracting a collagen solution with connective tissue cells. In the method of the present invention, the contraction of collagen fibrils by the connective tissue cells is restrained along an axis of cell alignment defined by at least two structural members within the gel, whereby the connective tissue cells align along the axis thereby producing an oriented tissue-equivalent. In a preferred embodiment fibroblast cells are used to contract a collagen gel to form connective tissue into a ligament configuration.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.