Heterocyclically substituted phenylacetic acid derivatives and their use in medicaments

US5521206A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Ulrich Muller · Wuppertal, DE
• Klaus-Helmut Mohrs · Wuppertal, DE
• Jurgen Dressel · Radevormwald, DE
• Rudolf Hanko · Düsseldorf, DE
• Walter Hubsch · Wuppertal, DE
• Michael Matzke · Wuppertal, DE
• Ulrich Niewohner · Wermelskirchen, DE
• Siegfried Raddatz · Hanerau-Hademarschen, DE
• Thomas Kramer · Wuppertal, DE
• Matthias Muller-Gliemann · Haan, DE
• Hans-Peter Belleman · Wuppertal, DE
• Martin Beuck · Milford, US
• Stanislav Kazda · Wuppertal, DE
• Stefan Wohlfeil · Hilden, DE

Key dates

• Filing date: Apr 15, 1994
• Grant date: May 28, 1996
• Expiry date: Apr 15, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to phenylacetic acid derivatives of the formula ##STR1## which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.