Process for preparing certain azapirones
US5521313A · kind A · utility
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8References
16Claims
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Assignee
Inventor
Key dates
| Filing date | May 5, 1994 |
| Grant date | May 28, 1996 |
| Priority date | — |
| Expiry date | May 5, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An improved process for preparation of certain useful azapirones, e.g. buspirone, gepirone, tandospirone, etc., comprises the reaction of a novel spiroquaternary piperazinium hydroxide with an appropriate imide to form imidate salts which are then converted to the azapirone by heating. This process is suitable for large scale adaptation and has advantages in greater safety and efficiency.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.