Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing
US5523219A · kind A · utility
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6References
24Claims
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Key dates
| Filing date | Jun 15, 1993 |
| Grant date | Jun 4, 1996 |
| Priority date | — |
| Expiry date | Jun 15, 2013 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2407/02
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
An enzymatic hydrolysis method, wherein one or more C-10 acyloxy-bearing taxanes are contacted with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. Also provided is an enzymatic esterification method, wherein one or more C-10 hydroxyl-bearing taxanes are contacted with an acylating agent and an enzyme or microorganism capable of esterifying said hydroxyl groups to form acyloxy groups.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.