Crystallization process for preparing glycerophosphocholine
US5523450A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 3, 1994 |
| Grant date | Jun 4, 1996 |
| Priority date | — |
| Expiry date | Oct 3, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/091
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for preparing substantially dry GPC (glycerophosphocholine in enantiomeric form) from wet GPC without racemisation, comprises subjecting the wet GPC to reduced pressure and elevated temperature, to reduce the water content and give highly viscous GPC; adding ethanol or another suitable solvent and crystallising GPC therefore with cooling; filtering the crystalline GPC and removing solvent therefrom under reduced pressure; characterised in that the elevated temperature is at least 45.degree. C.; and the solvent is added to the highly viscous GPC. This process produces an apparently new form of L-.alpha.-Glycerophosphocholine, m.p. 148.degree.-152.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.