Process for the preparation of 5-fluoroanthranilic acid

US5523472A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Freimund Rohrscheid · Kelkheim, DE
• Jochen Rapp · Frankfurt, DE
• Theodor Papenfuhs · Frankfurt, DE

Key dates

• Filing date: Oct 6, 1994
• Grant date: Jun 4, 1996
• Expiry date: Oct 6, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C227/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of 5-fluoroanthranilic acid, which comprises reacting 5-fluoro-2-bromotoluene in the presence of a catalyst and of an acidic solvent, with oxygen or an oxygen-containing gas at from 80.degree. to 220.degree. C., separating off the 5-fluoro-2-bromobenzoic acid formed and reacting it with ammonia at from 70.degree. to 180.degree. C.