Patent · US Expired

Serine-rich peptide linkers

US5525491A · kind A · utility

57Cited by

7References

19Claims

0Family size

Assignee

Creative BioMolecules, Inc. · US

Inventors

James S. Huston · Newton, US
Hermann Oppermann · Medway, US
Serge N. Timasheff · Wellesley, US

Key dates

Filing date	Jun 9, 1994
Grant date	Jun 11, 1996
Priority date	—
Expiry date	Jun 9, 2014

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/705
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Disclosed are serine-rich peptide linkers for linking two or more protein domains to form a fused protein. The peptide linkers contains at least 40% serine residues and preferably have the formula (Ser, Ser,Ser,Ser,Gly).sub.y where y is .gtoreq.1. The resulting fused domains are biologically active together or individually, have improved solubility in physiological media, and improved resistance to proteolysis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.