4-aminopyrimidine derivatives
US5525604A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 24, 1994 |
| Grant date | Jun 11, 1996 |
| Priority date | — |
| Expiry date | Aug 24, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D409/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A 4-aminopyrimidine of the formula (I): ##STR1## wherein A is a bond, C1-4 alkylene or C1-4 oxyalkylene; PA1 Y is a bond, C1-4 alkylene, C1-4 alkyleneoxy, C1-4 alkoxyphenylene or phenyl(C1-4)alkylene; PA1 Z is a bond or vinylene; PA1 R1 is 4-15 membered heterocyclic ring containing one or two nitrogen atom; PA1 R2 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one or two of oxygen or one sulfur atom, PA2 (ii) C4-15 carbocyclic ring, PA2 (iii) C1-4 alkoxy, PA2 (iv) hydroxy(C1-4 alkoxy) or PA2 (v) hydroxy; PA1 R3 is (i) 4-15 membered heterocyclic ring containing one or two nitrogen, one oxygen, one sulfur, or one nitrogen and one sulfur atom, PA2 (ii) C4-15 carbocyclic ring, PA2 (iii) formula: EQU CH2.dbd.CH(X)-- wherein PA1 X is halogen. PA2 (iv) hydrogen. PA1 l is 1 or 2. PA1 and some compounds are excluded. and acid addition salts thereof, salts thereof; have inhibitory effect on cGMP-PDE, or additionally on TXA2 synthetase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.