Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses
US5525621A · kind A · utility
7Cited by
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53Claims
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Key dates
| Filing date | May 20, 1994 |
| Grant date | Jun 11, 1996 |
| Priority date | — |
| Expiry date | May 20, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D233/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## wherein the substituents are as defined in the disclosure. The compounds are particularly useful for inhibiting damage to a variety of mammalian tissue that are jeopardized, for example, during runaway inflammatory conditions due to the damaging presence of singlet oxygen, the hydroxyl radical, cytokines and growth factors. The compounds are also useful in inhibiting damage to cardiac and central nervous system tissues during reperfusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.